The 16th Lyon Biennale: manifesto of fragility positions fragility at the heart of a generative form of resistance that is emboldened by the past, responsive to the present and primed for the future. In acknowledging fragility as one of few universally felt truths in our divided world, the Biennale assembles a host of creative practices and objects spanning two millennia that variously speak to the vulnerabilities of people and places, past and present, near and far. Conceived as a collective statement authored through word, image, sound and movement by 200 artists and creatives, it calls on a community of resilient voices to draft a manifesto for a world that is blamelessly fragile. The Biennale is structured around three distinct yet inter-connected layers, where fragility and resistance are explored through the lens of the individual, the city, and the world respectively.